Young writer Sal Paradise has his life shaken by the arrival of free-spirited Dean Moriarty and his girl, Marylou. As they travel across the country, they encounter a mix of people who each impact their journey indelibly.

A veteran assigned to extract Earth's remaining resources begins to question what he knows about his mission and himself.

Dave is a married man with three kids and a loving wife, and Mitch is a single man who is at the prime of his sexual life. One fateful night while Mitch and Dave are peeing in a fountain, lightning strikes and they switch bodies.